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Interdisciplinary Case Miles

15: High Hamstring Pain in Runners: Do You Need PRP or Is Rehab the Real Fix?

Mar 20, 2026 · 34 min · Ep 15

 Do You Need PRP or Is Rehab the Real Fix?

In Episode 15 of the Interdisciplinary Case Miles podcast, we discuss a case involving a 40-year-old age group runner whose long-standing hamstring tendinopathy became acutely aggravated after a slip on ice revealing the layered challenges of acute-on-chronic tendon pain in runners.

This case highlights why proximal hamstring injuries require precise diagnosis and an individualized treatment plan. Dr. Sara Raiser(MD) explains how to differentiate high hamstring tendinopathy from lumbar spine or nerve-related pain, when imaging such as MRI or diagnostic ultrasound is indicated, and how to determine whether a partial tear is present.

The conversation also covers when regenerative medicine options like platelet-rich plasma (PRP) injections or percutaneous tenotomy may be appropriate, and why they are rarely first-line treatment.

Dr. Kate Mihevc Edwards(PT) takes us through the rehabilitation process, including early integration after PRP, the role of blood flow restriction (BFR) training, and why eccentric strengthening remains the gold standard for tendon rehabilitation. She emphasizes addressing the entire kinetic chain hip mobility, lumbar and thoracic spine mechanics, neural tension, gait changes, and stiffness patterns that often contribute to chronic hamstring overload. You’ll also hear practical insight into return-to-run timelines, common pain spikes around the six-week mark post-PRP, and how to safely reload a healing tendon.

Sports dietitian Kelsey Pontius rounds out the discussion by explaining how nutrition directly influences tendon healing and regenerative outcomes.

The team discusses energy availability, protein targets, iron status, collagen-supporting micronutrients like vitamin C, zinc, and copper, and how fueling strategies can optimize recovery after procedures like PRP and during BFR training.

If you’re dealing with chronic hamstring pain, considering PRP for a running injury, or navigating a return to running after a proximal hamstring tear, this episode offers evidence-informed guidance from a running medicine physician, physical therapist, and sports dietitian working collaboratively to support runner health and performance.

If you’re enjoying these conversations, please follow the podcast and take a moment to rate or review it. Sharing it with a runner, coach, or healthcare provider helps us reach the people who can make the biggest difference in athletes’ lives. This podcast is for runners at every level, the coaches guiding them, and the healthcare professionals who care for them. We believe interdisciplinary care leads to better outcomes  and stronger runners.




00:00 – Welcome to Interdisciplinary Case Miles
Hosts introduce the case-based, evidence-informed discussion format.

02:00 – Case Presentation: High Hamstring Pain After a Slip
40-year-old runner with chronic hamstring tightness that became acute after slipping on ice.

05:00 – Why This Case Is Tricky
Chronic symptoms masked until an acute event; athletes often keep training through early tendon pain.

08:00 – Medical Evaluation Priorities
Rule out lumbar spine and nerve involvement; assess for proximal hamstring tendon injury vs referral.

12:00 – Timeline Matters: Acute on Chronic Injury
Long-standing tendon changes increase the likelihood of partial tearing with sudden load.

15:00 – Imaging Decisions: When and Why
MRI used to confirm tendon involvement and rule out hip pathology that can mimic hamstring pain.

18:00 – Why Rehab Comes First
Conservative care focuses on progressive loading, not rest, to restore tendon capacity.

21:00 – Key Biomechanics: Hip Extension Drives Load
Limited hip extension shifts demand to the hamstring, increasing strain and injury risk.

24:00 – When to Consider PRP or Tenotomy
Procedures introduced after failed rehab; choice depends on presence and size of tendon tear.

27:00 – PRP vs Tenotomy: Clinical Decision Making
PRP for larger tears; tenotomy for smaller or degenerative tendon changes

30:00 – Post-Procedure Management
Initial protection followed by gradual return to loading and early reintroduction of rehab.

33:00 – Rehab Progression After Intervention
Isometrics → eccentric loading → return to running with controlled progression.

36:00 – The Biggest Mistake Runners Make
Relying on passive treatments instead of structured strength and loading progression.

39:00 – Final Takeaways
Sara: Rule out spine and confirm diagnosis early
Kelsey: Recovery requires supporting the whole system
Kate: Tendons don’t heal with rest—they need progressive load

42:00 – Closing and Where to Learn More
Outro and resources for runners dealing with hamstring pain.



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